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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Radix ranunculus temate saponins
PubChem CID /
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
Ranunculus ternatus Warm
Chineses Pinyin MaoZhuaCao
Use Part Root tuber
Flavor Sweet; Pungent
Meridian Tropism Liver; Lung
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Ranunculales
    -->Family: Ranunculaceae
     -->Genus: Ranunculus
      -->Species: Ranunculus ternatus
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 205
Pair Name Radix ranunculus temate saponins, Paclitaxel
Partner Name Paclitaxel
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Gene Regulation Down-regulation Expression COL3A1 hsa1281
In Vitro Model A2780 Ovarian endometrioid adenocarcinoma Homo sapiens (Human) CVCL_0134
OVCAR-3 High grade ovarian serous adenocarcinoma Homo sapiens (Human) CVCL_0465
SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_0532
In Vivo Model A2780 cells (1×10⁶) were injected subcutaneously into the back of six-week-old BALB/c nu/nu female mice.
Result Combination of Taxol and RRTS may be a novel treatment strategy for patients with TR ovarian cancer.
04. Reference
No. Title Href
1 Radix ranunculus temate saponins sensitizes ovarian cancer to Taxol via upregulation of miR-let-7b. Exp Ther Med. 2022 May;23(5):315. doi: 10.3892/etm.2022.11244. Click
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